Pyrazolam (SH-I-04) is a sedative drug of the benzodiazepine class, first developed at Hoffman-La Roche in the 1970s. This drug affects benzodiazepine receptors (selective against subtypes of α2 and α3 receptors), the neurotransmitter gamma-aminobutyric acid (GABA), its effect as a consequence leads to a calming, sedative effect, euphoria and anticonvulsant properties and improved sleep.
The structure of pyrazolam is similar to alprazolam, etizolam with some minor differences, it contains a benzene ring fused with a diazepine ring with two nitrogen components at R1 and R4, a bromine molecule is bound to the structure at R7, and R6 is replaced by a 2-pyridine ring and contains a 1-methylated triazole ring connected to R1 and R2.
With regular use of this drug, tolerance and addiction can develop, and at high dosages, a number of side effects are possible, such as dizziness, loss of balance, respiratory depression. It is not recommended to take pyrazolam with other sedative preaprates and alcohol may enhance their effect. In some cases, an overdose of pyrazolam may cause uncontrolled aggression, irritability and suicidal behavior.
Pyrazolam in moderate dosages, has low toxicity and acts as an excellent sedative and anti-anxiety agent.
Pyrazolam is not banned in most countries of the world, but is a controlled or prescription drug in countries such as Germany, Switzerland, Sweden, the United Kingdom, Turkey and Canada.
Pyrazolam is a designer benzodiazepine drug and its toxicological and pharmacological properties are under investigation and not fully understood. This chemical is intended for research and identification of properties, in special rooms, on special laboratory equipment, in compliance with all safety measures.
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CAS | 39243-02-2 |
Product Name | Pyrazolam, Pirazolam |
Molecular Formula | C16H12BrN5 |
Molecular Weight | 354.20 |
IUPAC Name |
8-bromo-1-methyl-6-pyridin-2-yl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
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InChI |
InChI=1S/C16H12BrN5/c1-10-20-21-15-9-19-16(13-4-2-3-7-18-13)12-8-11(17)5-6-14(12)22(10)15/h2-8H,9H2,1H3
|
Solubility |
|
Synonyms | Pyrazolam, Pirazolam |
Purity | ≥98% |
Formulation | A crystalline solid, Powder |
Storage | -20°C |
Stability | ≥ 2 years |
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