O-Desmethyltramadol or O-DSMT for short (also called desmetramadol, Omnitram) is an opioid substance of the phenylpropylamine class, a highly active metabolite of tramadol with sedative and analgesic properties.
The structure of O-DSMT has a similar structure to tramadol, systematic name 3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol, and the actual does not apply to morphine opioids, and is more similar to codeine, it contains a cyclohexane ring associated with a phenyl ring in R1, which is replaced in R3 by a hydroxyl group, has an additional hydroxyl group, where the cyclohexane ring is connected to in the phenyl ring and has a third substitution on the ring in R2, which is connected to the dimethylamine group.
The atypicity of O-Desmethyltramadol in the form of its stereoisomers is a reflection of each other in three protections. The difference between O-DSMT and tramadol is in the absence of a methyl group in R3.
O-DSMT is a stronger agonist of the μ-opioid receptor than tramadol, and also affects the δ- and κ-opioid receptors.
O-DSMT is a norepinephrine reuptake inhibitor, but is not active as a serotonin reuptake inhibitor, which makes it useful in the treatment of various types of pain.
This drug affects the m-opioid receptors, activating them they mimic endorphins, which leads to euphoria and anxiolytic effect, anxiety suppression and relaxation.
The action of O-DSMT is less active compared to morphine.
It is not recommended to mix this drug with other opioid, benzodiazepine and other drugs and alcohol, as this can lead to unpredictable consequences and side effects.
This drug can be called moderately addictive and can cause psychological dependence. The development of tolerance is possible with repeated use of O-Desmethyltramadol.
This drug is a designer chemical and many countries do not regulate its sale and purchase for research purposes, but this drug is already a controlled substance in Germany, Sweden, Switzerland and the UK.
O-DSMT is a designer opioid drug and its toxicological and pharmacological properties are under investigation and not fully understood. This chemical is intended for research and identification of properties, in special rooms, on special laboratory equipment, in compliance with all safety measures.
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| CAS | 80456-81-1 |
| Product Name | O-Desmethyltramadol, O-DSMT, desmetramadol, Omnitram, (+)-O-Desmethyltramadol |
| Molecular Formula | C15H23NO2 |
| Molecular Weight | 249.354 g·mol−1 |
| IUPAC Name | 3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol |
| InChI |
InChI=1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1
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| Solubility |
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| Synonyms | O-Desmethyltramadol, O-DSMT, desmetramadol, Omnitram, (+)-O-Desmethyltramadol |
| Purity | ≥98% |
| Formulation | A crystalline solid |
| Storage | -20°C |
| Stability | ≥ 2 years |
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